Resume Details

Personal Information
Name: Zahra Hasan
Discipline: Pharmaceutical & BioMedical Sciences Institution: Agha Khan University
Gender: Female Department: Pathology and Microbiology
Specialization: Immunology, Molecular Pathology Present Position: Associate Professor
Address: Stadium Road, P.O. Box 3500 Karachi 74800 City: Karachi
Email: zahra.hasan@aku.edu Phone: 021 3486 4527
Fax: 021 3493 4294 CNIC:

Education History
Year
Degree
Field of Study
Institution/University
1993
B.Sc(Hons) Biochemistry Imperial College of Science, Technology and Medicine, University of London, UK
1997
PhD Molecular Microbiology Imperial College of Science, Technology and Medicine, University of London, UK

 Professional Experience
Institution/ Organization
Position / Job Title
Period
From
To
Aga Khan University, Karachi Associate Professor
1998
2011
Basel Institute for Immunology, Switzerland Visiting Scientist
1997
1998

Research Interests
  Immunology of infectious diseases; Tuberculosis research

 Publications in Journals
1. 33. JQ.Farouqi, E Khan, SMZ Alam, A Ali, "Line probe assay for detection of rifampicin and isoniazid resistant tuberculosis in Pakistan" (2012) J P M A Vol:Accepted pp:- (Journal)
2. R. Hasan and S. Tahseen "Overcoming M. tuberculosis drug resistance" (2012) Eur Clin Dis Vol:Accepted pp:- (Journal)
3. A Ayaz, S Jafri, R Mehboob, R Manghi, A Channa, F Malik, A Ali, Y Rafiq, R Hasan "Characterising M. tuberculosis in Karachi, Pakistan: Drug resistance patterns, genotypes and risk factors for drug resistant TB" (2012) Int J Infect Dis Vol:Accepted pp:- (Journal)
4. 33. JQ.Farouqi, E Khan, SMZ Alam, A Ali, Z Hasan and R Hasan "Line probe assay for detection of rifampicin and isoniazid resistant tuberculosis in Pakistan" (2012) J Pak Med Assoc Vol:Accepted pp:- (Journal)
5. A Zafar, M Stone, S Ibrahim, Z Parveen E Khan, R Hasan, J Wain and K Bamford "Prevalent Genotypes of Methicillin Resistant Staphylococcus aureus; Report from Pakistan" (2011) J Med Microbiol Vol:60 pp:56-62 (Journal)
6. Y Rafiq, Kauser Jabeen, S Jafri "Fluoroquinolone resistance amongst Mycobacterium tuberculosis strains from Karachi, Pakistan; Data from community based field clinics" (2011) Antimicro Ag Chemo Vol:55 pp:929-930 (Journal)
7. A Kanji, M Tanveer, R Laiq and R Hasan "Occurrence of RD149 and RD152 deletions in M. tuberculosis strains from Pakistan" (2011) J Infect Dev Cntries Vol:5 pp:106-113 (Journal)
8. R Hussain, N Talat, A Ansari, F Shahid and G Dawood "Endogenously activated Interleukin-4 differentiates disease progressors and non-progressors in tuberculosis susceptible families. A 2-year biomarkers follow up study" (2011) J Clin Immunol Vol:31 pp:913-923 (Journal)
9. A. Kanji, M. Tanveer, R. Mahboob, S. Jafri, and R. Hasan "Presence of RD149 deletions in the M. tuberculosis Central Asian Strain1 isolates affect growth and TNFa induction in THP-1 monocytes" (2011) PLoS One Vol:6 pp:e24178- (Journal)
10. Nisar Rao, Naseem Salahuddin, Muniba Islam, Mussarat Ashraf, Bushra Jamil, Martin E. Rottenberg and Rabia Hussain "M. tuberculosis sonicate induced cytokines can differentiate severity of tuberculosis " (2011) Scan J Immunol Vol:doi:10.1111/j.1365-3083.2011.02642.x pp:- (Journal)
11. Rabia Hussain, Ambreen Ansari, Najeeha Talat "CCL2/MCP-I genotype-phenotype relationship in latent tuberculosis infection" (2011) PLoS ONE Vol:6 pp:e25803- (Journal)
12. Asho Ali, Rumina Hasan, Kausar Jabeen, Nusrat Jabeen "Characterisation of mutations conferring extensive drug resistance (XDR) to M. tuberculosis isolates in Pakistan" (2011) Antimicrobial Agents and Chemotherapy Vol:55 pp:5654-5659 (Journal)
13. R Hasan, K Jabeen, M Tanveer, A Ali, Y Rafiq, R Laiq, B Malik, R Petersson, S Ghebremichael, S Hoffner "Extensively Drug Resistant Tuberculosis, Pakistan" (2010) Emrg Infect Dis Vol:6 pp:1473-1475 (Journal)
14. B Jamil, M Ashraf, M Islam, M Dojki, M Irfan and R Hussain "Differential live M. tuberculosis , BCG-, and recombinant ESAT6- and CFP10- induced immunity in tuberculosis" (2009) Clin Vac Immunol Vol:16 pp:991-998 (Journal)
15. CCL2 responses to Mycobacterium tuberculosis are associated with disease severity in tuberculosis "CCL2 responses to Mycobacterium tuberculosis are associated with disease severity in tuberculosis" (2009) PLoS One Vol:4 pp:e8459- (Journal)
16. B. Jamil, J. Khan, R. Ali, N. Nasir, M. A. Khan, S. Yusuf, S. Jamil, M. Irfan and R. Hussain "Relationship between Circulating Levels of IFN, IL10, CXCL9 and CCL2 in Pulmonary and Extrapulmonary Tuberculosis is Dependent on Disease Severity" (2009) Scan J Immunol Vol:69 pp:259-267 (Journal)
17. M. Tanveer, A. Kanji and R. Hasan "Reduced TNF-alpha and IFN-gamma responses to Central Asian strain 1 and Beijing isolates of M.tuberculosis as compared with H37Rv" (2009) Trans R Soc Trop Med Vol:103 pp:581-587 (Journal)
18. S.Shakoor, M Tanveer and R Hasan "Prevalence of M. tuberculosis genogroup ST26 among treatment nave tuberculosis patients from Karachi indicating ongoing transmission" (2009) Scan J Infect Dis Vol:13 pp:1-6 (Journal)
19. Ansari, N. Talat, B. Jamil, T. Razzaki, G. Dawood and R. Hussain "Distinct cytokine genotype combinations in the Pakistani patients are associated with disease severity in pulmonary and extra-pulmonary tuberculosis" (2009) PLoS One Vol:4 pp:e4478- (Journal)
20. B Jamil, M Ashraf, M Islam, M.S. Yusuf, J.A. Khan and R Hussain. "ESAT6-induced IFNgamma and CXCL9 can differentiate severity of tuberculosis" (2009) PLoS One Vol:4 pp:e5158- (Journal)
21. A. Ali, T. Moatter, M. Tanveer, R. Hasan "CAS1 MDR strain is more prone to mutations in rpoB and katG genes as compared with Beijing MDR strains" (2009) Scan J Infect Dis Vol:41 pp:37-44 (Journal)
22. M. Tanveer, S. Ghebremichael and R. Hasan "Genotyping and Drug resistance patterns of M. tuberculosis strains in Pakistan: Description of phylogenetically prevalent clades" (2008) BMC Infect Dis Vol:8 pp:171- (Journal)
23. "Challenges of Biological sciences research in Pakistan" (2007) J Infect Dev Cntries Vol:1 pp:87-89 (Journal)
24. A. Ali, M. Tanveer, R. Siddiqui, S. Ghebremichael, G. Kallenius and R. Hasan "Characterization of Mycobacterium tuberculosis Central Asian Strain1 using mycobacterial interspersed repetitive unit genotyping" (2007) BMC Microbiol Vol:7 pp:76- (Journal)
25. Jamil, B., F. Shahid, N. Nasir, T. Razzaki, G. Dawood, and R. Hussain "Interferon γ : IL10 ratio defines the severity of disease in pulmonary and extra-pulmonary tuberculosis" (2007) Tuberculosis Vol:87 pp:279-287 (Journal)
26. M. Ashraf, A. Tayyebi and R. Hussain "M. leprae induces a lower rate of apoptosis as compared with BCG by downregulation of Bad and Bak and upregulation of Mcl-1 expression" (2006) BMC Microbiol Vol:6 pp:78- (Journal)
27. M. Ashraf, A. Tayyebi and R. Hussain "M. leprae induces a lower rate of apoptosis as compared with BCG by downregulation of Bad and Bak and upregulation of Mcl-1 expression" (2006) BMC Microbiol Vol:6 pp:78- (Journal)
28. M. Tanveer, A. Kanji, Q. Hasan and R. Hasan "Spoligotyping of Mycobacterium tuberculosis isolates in Pakistan reveals predominant Central Asian and Beijing strains" (2006) J Clin Micro Vol:44 pp:1221-1225 (Journal)
29. R. Hussain, B. Jamil, I. Zaidi "Elevated serum CCL2 concomitant with a reduced Mycobacterium-induced response leads to disease dissemination in leprosy" (2006) Scan J Immuno Vol:63 pp:241-247 (Journal)
30. "Avian Flu diagnostics" (2005) Infect Dis J Pak Vol:4 pp:135-136 (Journal)
31. I., Zaidi, Jamil, B., Khan, M. "Elevated ex vivo monocyte chemotactic protein-1 (CCL2) in pulmonary as compared with extra-pulmonary tuberculosis" (2005) BMC Immunology Vol:6 pp:14- (Journal)
32. A. Mahmood, Zafar, S., Khan, A "Leprosy patients with lepromatous disease have an up-regulated IL-8 response that is unlinked to TNFα responses" (2004) Int. J. Lepr othe Mycobact Dis Vol:72 pp:35-44 (Journal)
33. S.M. Thakurdas and R. Hussain "IgG1 anti-mycobacterial antibodies can reverse the inhibitory effect of Pentoxifylline on tumor necrosis factor alpha (TNF-α) secreted by mycobacterial antigen stimulated monocytes" (2004) Clin. Exp. Immunol Vol:136 pp:320-327 (Journal)
34. B.H., Shah, Mahmood, A., Young "The effect of mycobacterial virulence and viability on MAP kinase signaling and TNF production by human monocytes" (2003) Tuberculosis Vol:82 pp:299-309 (Journal)
35. "Real time PCR for rapid quantitation of genes and its applications" (2003) Infect. Dis. J. Pak Vol:4 pp:115-118 (Journal)
36. "Vaccines: considerations for the generation of protective immunity" (2002) Infect. Dis. J. Pak Vol:3 pp:84-86 (Journal)
37. "The Human Genome Mapping Project and its implications" (2000) Infec. Dis. J. Pak Vol:1 pp:2-3 (Journal)
38. V.A. Snewin, Gares, M.P., Gaora "Assessment of immunity to mycobacterial infection with luciferase reporter construct" (1999) Infection and Immunity Vol:67 pp:4586-4593 (Journal)
39. "PCR - the genetic engineers photocopier - and its applications in Clinical Microbiology" (1999) Infect Dis J Pak Vol:4 pp:30-32 (Journal)
40. J. Pieters "Subcellular fractionation by organelle electrophoresis: separation of phagosomes containing heat-killed yeast particles" (1998) Electrophoresis Vol:19 pp:1179-1184 (Journal)
41. C. Schlax, Kuhn, L., Lefkovitz "Isolation and characterisation of the mycobacterial phagosome: segregation from the endosomal/lysosomal pathway" (1997) Molecular Microbiology Vol:24 pp:545-553 (Journal)

 Other Publications
1. A. Ali and R. Hasan "Molecular Epidemiology of Mycobacterium tuberculosis" (2008) Infect Dis J Pak Vol:17 pp:61-65 (Journal)
2. A. Pawlowski, N. Vivar and G. Kallenius "BCG-induced apoptosis in human monocytes is dependent on MAPK, PTK and PI-3 kinase pathways" (2007) J Med Sci Vol:7 pp:1157-1163 (Journal)

Post-Graduate Supervision
Type Role  No. of Students Supervised & Awarded Degrees  No. of Students In Progress
HEC Funded Non-HEC Funded
PhD Co-Supervisor 2 1 1
PhD Supervisor 1

Students Supervised
Name of student
Dissertation
Title
Year of graduation
Mahnaz Shafaat PhD Characterisation of Mycobacterium tuberculosis Beijing strains in Pakistan using molecular and immunological techniques
2009
Asho Ali PhD Genetic diversity and molecular basis of antimicrobial resistance of Mycobacterium tuberculosis strains from Pakistan
2009
Akbar Rasool Kanji PhD Analysis of M. tuberculosis deletions
2012

 Research Grants/Projects
1. "Chemokines as immunopathological markers in tuberculosis infections"  ($70,000)  By: TDR, WHO, Switzerland  (2004-2006)  Zahra Hasan  Rabia Hussain 
2. "2004-2007 Association of genetic diversity with virulence and antimicrobial resistance in M. tuberculosis isolates at the AKUH"  ($ 28,000)  By: URC, AKU, Pakistan  (2004-2007)  Asho Ali  Zahra Hasan, Rumina Hasan 
3. "2003-2005 Evaluation of the frequency of Beijing strainsof M. tuberculosis in Pakistan Detection of rpoB genotype within isola"  ($ 28,000)  By: URC, AKU, Pakistan  (2003-2005)  Rumina Hasan  Zahra Hasan, 
4. "Laboratory Markers of Risk for clinical disease in household contacts of tuberculosis patients"  (Rs 3 million)  By: Ministry S & T, Pakistan  (2003-2005)  Rabia Hussain  Zahra Hasan, Rumina Hasan 
5. "Mycobacterium tuberculosis -induced host cellular activation: effect on cytokine expression and signaling"  ($ 24,500)  By: URC, AKU, Pakistan  (2003-2006)  Zahra Hasan  Rabia Hussain 
6. "Cytokine responses in patients with pulmonary and extrapulmonary tuberculosis"  ($ 10,000)  By: Seed Grant, AKU, Pakistan  (1999-2002)  Zahra Hasan  Rabia Hussain 
7. "Macrophage signaling and cytokine expression in leprosy patients with lepromatous disease"  ($ 40,000)  By: TDR, WHO, Switzerland  (1999-2001)  Zahra Hasan  Rabia Hussain 
8. "Mycobacterium tuberculosis-induced apoptosis in human macrophages"  ($ 8,000)  By: Seed Grant, AKU, Pakistan  (2003-2005)  Ali Tayebbi  Zahra Hasan 
9. "Vitamin D replacement and recovery from pulmonary TB"  ($32776)  By: URC, AKUH, Pakistan  (2009-2011)  Nawal Salahuddin  Nisar Rao, Zahra Hasan, Faisal Mahmood, Farheen Ali 
10. "Prevalence of Mycobacterium tuberculosis strain types in Karachi and their association with drug resistance"  ($70000)  By: Bennenden Society, UK  (09/1/2006-12/31/2010)  Rumina Hasan  Zahra Hasan 
11. "Chemokines and experimental dissection of cellular immune responses in the outcome of mycobacterial infections"  ($15000)  By: ASIA-Link Program Grant, Swedish Research Council, Sweden  (08/1/2006-07/31/2009)  Zahra Hasan  Martin E Rottenberg 
12. "Regulation and role of Suppressor of Cytokine Signaling proteins in the outcome of infection with Mycobacterium tuberculosis"  ($30000)  By: ASIA Link Program Grant, Swedish Research Council, Sweden  (09/1/2009-10/1/2012)  Zahra Hasan  Martin E. Rottenberg 
13. "Role of regulatory T cells in disease severity in extrapulmonary TB"  ($23400)  By: URC, AKUH, Pakistan  (2008-2011)  Kiran Iqbal  Zahra Hasan, M.E Rottenberg, Rabia Hussain 
14. "Characterisation of drug resistant mutations in extensively drug resistant (XDR) Mycobacterium tuberculosis strains in Pakistan"  ($9000)  By: EMRO TDR Small Grants Program  (09/1/2009-03/31/2011)  Zahra Hasan  Rumina Hasan, Kausar Jabeen and Asho Ali 
15. "Antimicrobial resistance in Pakistan: A program to develop and strengthen capacity for surveillance, containment and diagnosis through public-private sector partnership"  ($600,000)  By: Pak-US Joint project proposal, S & T ministry, Pakistan and USAIN  (09/1/2006-12/20/2010)  Rumina Hasan and Mary Brandt  Zahra Hasan, Afia Zafar, Bushra Jamil, Rabia Hussain 
16. "Molecular epidemiology and deletion analysis of Mycobacterium tuberculosis strains associated with pulmonary and extrapulmonary tuberculosis"  ($14500)  By: URC, AKU, Pakistan  (2008-2010)  Akbar Kanji  Zahra Hasan, Rumina Hasan 
17. "Effect of biomass smoke on the immune response"  ($5000)  By: Seed Grant, AKUH, Pakistan  (2009-2010)  Ambreen Kazi  Zafar Fatmi, Zahra Hasan 
18. "Do single nucleotide polymorphisms in CC chemokines (CCL2 and CCL1) determine disease severity and susceptibility to TBin Pakistan"  (Rs 1.8 million)  By: Pakistan Academy of Sciences  (2010-2012)  Rabia Hussain  Zahra Hasan and Ambreen Ansari 

Last Updated: Friday, August 12, 2011